Around 7.20am police in an unmarked car came across a white van driving in a carpark at the intersection of Heatherton Road and James Street, Dandenong North.
The van rammed the unmarked police car twice before an officer got out of the car and fired two shots at the van as it drove away on Heatherton Road.
It is unknown if the shots made contact with the van.
Police are investigating the incident with oversight by Professional Standards Command.